Home › Products › Retatrutide
GLP-1 / GIP / Glucagon Tri-Agonist

Retatrutide (LY3437943)

⚠️ FOR RESEARCH USE ONLY. This compound is not intended for human or veterinary consumption. Not approved by the FDA. Purchasers assume all legal responsibility for use.
99.5%+
HPLC Purity
Retatrutide 12mg Research Vial
≥99.5% Purity 4731.4 Da MW Lyophilized US Stock

Compound Overview

IUPAC Name Retatrutide
Research ID LY3437943
Receptor Targets GLP-1R, GIPR, GcgR
Molecular Weight 4731.4 Da
Form Lyophilized powder
Storage -20°C, desiccated
Solubility Water / PBS / DMSO
Classification Research Use Only
Featured Compound In Stock RUO

Triple receptor agonist targeting GLP-1R, GIPR, and glucagon receptor simultaneously. Under active investigation in metabolic signaling research. Third-party HPLC verified, ≥99.4% purity, COA available.

Select Quantity / Size
$86.00
per 12mg vial · Research Grade · Lyophilized
1 vials
⚡ Buy Now — Secure Checkout
🚚Ships in 48 hours — US Warehouse Stock
🔐Discreet packaging — No product branding outside
❄️Cold-chain protected — Ships with ice pack
💳Secure payment — Card, ACH, or Crypto
⚠️ RESEARCH USE ONLY. This compound is not intended for human consumption, therapeutic use, or veterinary application. Not approved by the FDA. By purchasing, you confirm you are a qualified researcher and assume full legal responsibility.

About Retatrutide (LY3437943)

Retatrutide is a synthetic long-acting peptide that acts simultaneously as a triple agonist at the glucagon-like peptide-1 receptor (GLP-1R), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon receptor (GcgR). This unique triple-agonist profile has made it a subject of intense scientific investigation.

As a research compound classified for Research Use Only (RUO), Retatrutide has been the subject of numerous preclinical investigations focusing on metabolic receptor signaling, adipose tissue dynamics, hepatic glucose production, and related biochemical pathways.

⚠️ VialX supplies this compound exclusively for in vitro and laboratory research. No medical or therapeutic claims are made or implied.

Research Applications

The following represent documented in vitro and preclinical research contexts (not therapeutic recommendations):

  • ▸GLP-1 receptor binding affinity studies
  • ▸Triple incretin axis signaling pathway research
  • ▸Adipocyte lipolysis signaling in cell models
  • ▸Hepatic glucagon receptor studies
  • ▸Peptide structure-activity relationship (SAR) analysis
  • ▸Comparative tri-agonist binding kinetics

Storage & Handling Guidelines

❄️
-20°C Storage
Keep frozen when not in use
💧
Reconstitution
Use sterile water or PBS
🔬
In Vitro Only
Research grade — RUO
📅
2-Year Shelf Life
Lyophilized, unopened

Third-Party Lab Results — Retatrutide 12mg

All batches are independently tested by trusted community labs before sale. Results are publicly verifiable using the keys below.

99.5%+
Avg. HPLC Purity
3
Independent Tests
2
Labs (PT + Janoshik)
✓
Identity Verified
PeptideTest · TrustPointe LIMS
Published: 2026-03-26 · Batch: 967285-000006 (black cap)
Sample: Retatrutide 12mg · Mfg: Aavant, RO
Verify · Key: KJQK9VVGQ9HA ↗
Sample IDSPL-3328
Sample ID (replicate)SPL-3328-S01
Assay (mg)16.072 mg
Assay — replicate16.760 mg
HPLC Purity99.134%
HPLC Purity — replicate99.222%
ID by RT1.00 ✓
ID by Spectral1000 ✓
Coelution1000 ✓
System Suitability0.7 %RSD ✓
Signed: Ashlee Lust (President) · Reviewed: Joshua Lust (Managing Director) · www.peptidetest.com
PeptideTest · TrustPointe LIMS
Published: 2026-03-03 · Batch: 967286-000005 (black cap)
Sample: Retatrutide 12mg · Mfg: Aavant, RO
Verify · Key: JHVPN9WSEMWM ↗
Sample IDSPL-3221
Sample ID (replicate)SPL-3221-S01
Assay (mg)15.450 mg
Assay — replicate15.467 mg
HPLC Purity99.585%
HPLC Purity — replicate99.512%
ID by RT1.00 ✓
ID by Spectral1000 ✓
Coelution1000 ✓
System Suitability0.5 %RSD ✓
Signed: Ashlee Lust (President) · Reviewed: Joshua Lust (Managing Director) · www.peptidetest.com
Janoshik Independent Lab
Task #96496 · Analysis: 06 JAN 2026 · Batch: 967286-000004 (black cap)
Sample: Retatrutide 12mg · Client: Aavant · Mfg: Aavant (ACR)
Verify · Key: BACTSHBESIDZ ↗
Retatrutide (vial 1)13.28 mg
Retatrutide (vial 2)13.60 mg
Purity (vial 1)99.666%
Purity (vial 2)99.667%
Testing ordered25 DEC 2025
Sample received31 DEC 2025
www.janoshik.com · info@janoshik.com

All results are independently verifiable using the keys above. COA PDFs available on request via the contact page.

Research Background

The following is a summary of published scientific literature on Retatrutide. All information is provided for informational and research context only. VialX makes no therapeutic claims.

Nature Medicine · 2023 · Phase 2 Clinical Data

Triple Hormone Receptor Agonism in Metabolic Research

Published research has investigated the pharmacodynamic profile of retatrutide, demonstrating simultaneous agonism at GLP-1R, GIPR, and glucagon receptors. Preclinical data showed significant effects on adipose tissue and hepatic function in animal models (for research context only).

Journal of Clinical Endocrinology · 2024

GLP-1/GIP/Glucagon Tri-Agonist Receptor Binding Kinetics

Studies characterizing the binding affinity of triple incretin agonists to their respective GPCRs. Researchers have noted differential potency ratios at GLP-1R vs. GIPR vs. GcgR which may be relevant for in vitro dose-response modeling.

Diabetes · 2023

Adipocyte Signaling Studies with Triple Agonists

In vitro research examining the downstream signaling cascades activated in adipocyte cell lines exposed to triple receptor agonists. cAMP accumulation assays and downstream MAPK pathway analysis have been areas of particular interest.

⚠️ Research Context Disclaimer: The above represents a summary of scientific literature for research context purposes only. VialX does not sell Retatrutide for any therapeutic, clinical, or human use purpose. All references are to published scientific investigations, not to product efficacy claims.

Frequently Asked Questions

What does "Research Use Only" (RUO) mean?

RUO means the compound is intended solely for in vitro laboratory and scientific research. It is NOT approved for human consumption, therapeutic use, clinical trials without IND approval, or veterinary use. Purchasers assume full legal responsibility.

Is Retatrutide legal to purchase for research?

Retatrutide is a synthetic research peptide that is not currently a scheduled controlled substance in the US. However, laws vary by jurisdiction and change over time. You are solely responsible for understanding and complying with all applicable laws in your area.

How is the product shipped?

All orders ship from our US-based fulfillment warehouse within 48 hours of payment confirmation. Products are shipped in plain, discreet packaging with cold packs for peptides. Domestic shipping typically takes 2–5 business days.

Do you offer a COA for every batch?

Yes. A Certificate of Analysis is available for every batch we sell. The COA includes HPLC purity data, mass spectrometry identity confirmation, and batch-specific lot numbers. Contact us to request a full PDF COA.

What payment methods do you accept?

We accept major credit/debit cards via our secure checkout, ACH bank transfer, and cryptocurrency (Bitcoin, USDC). All payments are processed through our secure checkout portal.

Do you have a return policy?

Due to the nature of research compounds, we do not accept returns on opened products. Damaged or incorrectly shipped items will be replaced at no cost. Contact our team within 7 days of delivery for any issues.

Related Research Compounds

BPC-157 5mg
BPC-157
$49.00
Out of Stock
CJC-1295 2mg
CJC-1295
$45.00
Out of Stock
TB-500 5mg
TB-500
$59.00
Out of Stock

🛒 Research Cart

🧪

Your cart is empty.

✅Added to cart